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DeForest Lab Publications

DeForest Lab Cover Gallery

Selected Publications

  • Kopyeva, I., Brady, R.P. & DeForest, C.A. Light-based Fabrication and 4D Customization of Hydrogel Biomaterials. Nature Reviews Bioengineering (In Press, 2024). (link, pdf)
  • Rapp, T.L., Kopyeva, I., Adhikari, A. & DeForest, C.A. Bioluminescence Resonance Energy Transfer (BRET)-mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials. Journal of the American Chemical Society, In Press. (2024). (link, pdf)
  • Kopyeva, I., Goldner, E.C., Hoye, J.W., Yang, S., Regier, M.C., Bradford, J.C., Vera, K.R., Bretherton, R.C., Robinson, J.L. & DeForest, C.A. Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Interpenetrating Networks. Advanced Materials, In Press. (2024). (link, pdf)
  • Mout, R., Bretherton, R.C., Decarreau, J., Lee, S., Gregorio, N., Edman, N.I., Ahlrichs, M., Hsia, Y., Sahtoe, D.D., Ueda, G., Schulman, R., DeForest, C.A.* & Baker, D.* De Novo Design of Modular Protein Hydrogels with Programmable Intra- and Extracellular Viscoelasticity. Proceedings of the National Academy of Sciences of the United States of America, 121, e2309457121 (2024). (link, pdf) *Co-Corresponding Authorship
  • DeForest, C.A.*, Kirkpatrick, B.E. & Anseth, K.S.* Engineering Native Biological Complexity from the Inside–out and Outside–in. Nature Chemical Engineering, 1, 2-5 (2024). (link, pdf) *Co-Corresponding Authorship
  • Rapp, T.R. & DeForest, C.A. Tricolor Visible Wavelength-selective Photodegradable Hydrogel Biomaterials. Nature Communications, 14, 5250 (2023). (link, pdf)
  • Ruskowitz, E.R., Munoz-Robles, B.G., Strange, A.C., Butcher, C.H., Kurniawan, S., Filteau, J.R. & DeForest, C.A. Spatiotemporal Functional Assembly of Split Protein Pairs through a Light-Activated SpyLigation. Nature Chemistry, 15, 694–704 (2023). (link, pdf)
  • Bretherton, R.C., Haack, A.J., Kopyeva, I., Rahman, F., Kern, J.D., Bugg, D., Theberge, A.B., Davis, J. & DeForest, C.A. User-controlled 4D Biomaterial Degradation with Substrate-selective Sortase Transpeptidases for Single-cell Biology. Advanced Materials, 35, 2209904 (2023). (link, pdf)
  • Batalov, I., Stevens, K.R. & DeForest, C.A. Photopatterned Biomolecule Immobilization to Guide 3D Cell Fate in Natural Protein-based Hydrogels. Proceedings of the National Academy of Sciences of the United States of America, 118, e2014194118 (2021). (link, pdf)
  • Shadish, J.A., Strange, A.C. & DeForest, C.A. Genetically Encoded Photocleavable Linkers for Patterned Protein Release from Biomaterials. Journal of the American Chemical Society, 141, 15619-15625 (2019). (link, pdf)
  • Shadish, J.A., Benuska, G.M. & DeForest, C.A. Bioactive Site-Specifically Modified Proteins for 4D Patterning of Gel Biomaterials. Nature Materials, 18, 1005-1014 (2019). (link, pdf)
  • Badeau, B.A., Comerford, M.P., Arakawa, C.K., Shadish, J.A. & DeForest, C.A. Engineered Modular Biomaterial Logic Gates for Environmentally Triggered Therapeutic Delivery. Nature Chemistry, 10, 251-258 (2018). (link, pdf)
  • Ruskowitz, E.R. & DeForest, C.A. Photoresponsive Biomaterials for Targeted Drug Delivery and 4D Cell Culture. Nature Reviews Materials, 3, 17087 (2018). (link, pdf)
  • Arakawa, C.K., Badeau, B.A., Zheng, Y. & DeForest, C.A. Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation. Advanced Materials, 29, 1703156 (2017). (link, pdf)
  • DeForest, C.A.* & Tirrell, D.A.* A Photoreversible Protein-Patterning Approach for Guiding Stem Cell Fate in Three-Dimensional Gels. Nature Materials, 14, 523-531 (2015). (link, pdf) *Co-Corresponding Authorship
  • DeForest, C.A. & Anseth, K.S. Photoreversible Patterning of Biomolecules within Click-based Hydrogels. Angewandte Chemie International Edition, 51, 1816-1819 (2012). (link, pdf)
  • DeForest, C.A. & Anseth, K.S. Cytocompatible Click-based Hydrogels with Dynamically-Tunable Properties through Orthogonal Photoconjugation and Photocleavage Reactions. Nature Chemistry, 3, 925-931 (2011). (link, pdf)
  • DeForest, C.A., Polizzotti, B.D. & Anseth, K.S. Sequential Click Reactions for Synthesizing and Patterning 3D Cell Microenvironments. Nature Materials 8, 659-664 (2009). (link, pdf)
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    Full Publication List

  • Kopyeva, I., Brady, R.P. & DeForest, C.A. Light-based Fabrication and 4D Customization of Hydrogel Biomaterials. Nature Reviews Bioengineering (In Press, 2024). (link, pdf)
    • Light-based Fabrication and 4D Customization of Hydrogel Biomaterials
  • DeForest, C.A. Book Review for Book Review for “How to Make Your PhD Work” by Thomas R. Coughlin. Chemical Engineering Education (In Press, 2024). (link, pdf)
    • Book Review for Book Review for “How to Make Your PhD Work” by Thomas R. Coughlin
  • Rapp, T.L., Kopyeva, I., Adhikari, A. & DeForest, C.A. Bioluminescence Resonance Energy Transfer (BRET)-mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials. Journal of the American Chemical Society, In Press. (2024). (link, pdf)
    • Bioluminescence Resonance Energy Transfer (BRET)-mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials
  • Kopyeva, I., Goldner, E.C., Hoye, J.W., Yang, S., Regier, M.C., Bradford, J.C., Vera, K.R., Bretherton, R.C., Robinson, J.L. & DeForest, C.A. Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Interpenetrating Networks. Advanced Materials, In Press. (2024). (link, pdf)
    • Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Interpenetrating Networks
  • Gharios, R., Li, A., Kopyeva, I., Francis, R.M. & DeForest, C.A. One-Step Purification and N-terminal Functionalization of Bioactive Proteins via Atypically Split Inteins. Bioconjugate Chemistry, 35, 750-757 (2024). (link, pdf)
    • One-Step Purification and N-terminal Functionalization of Bioactive Proteins via Atypically Split Inteins
  • Bennett, J.I., Boit, M.O., Gregorio, N.E., Zhang, R., Kibler, R.D., Hoye, J.W., Prado, O., Rapp, P.E., Murry, C.E., Stevens, K. & DeForest, C.A. Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies. Advanced Science 11, 2301708 (2024). (link, pdf)
    • *This article appears on the cover of the June 2024 issue of Advanced Science Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies
  • Nealy, E.S., Reed, S.J., Adelmund, S.M., Badeau, B.A., Shadish, J.S., Girard, E.J., Brasel, K., Pakiam, F., Mhyre, A., Price, J., Sarkar, S., Kalia, V., DeForest, C.A.* & Olson, J.M.* Versatile Tissue-Injectable Hydrogels Capable of the Extended Hydrolytic Release of Bioactive Protein Therapeutics. Bioengineering & Translational Medicine (In Press, 2024). (link, pdf) *Co-Corresponding Authorship
    • *This article appears on the cover of the September 2024 issue of Bioengineering & Translational Medicine ersatile Tissue-Injectable Hydrogels Capable of the Extended Hydrolytic Release of Bioactive Protein Therapeutics
  • Mout, R., Bretherton, R.C., Decarreau, J., Lee, S., Gregorio, N., Edman, N.I., Ahlrichs, M., Hsia, Y., Sahtoe, D.D., Ueda, G., Schulman, R., DeForest, C.A.* & Baker, D.* De Novo Design of Modular Protein Hydrogels with Programmable Intra- and Extracellular Viscoelasticity. Proceedings of the National Academy of Sciences of the United States of America, 121, e2309457121 (2024). (link, pdf) *Co-Corresponding Authorship
    • De Novo Design of Modular Protein Hydrogels with Programmable Intra- and Extracellular Viscoelasticity.
  • DeForest, C.A.*, Kirkpatrick, B.E. & Anseth, K.S.* Engineering Native Biological Complexity from the Inside–out and Outside–in. Nature Chemical Engineering, 1, 2-5 (2024). (link, pdf) *Co-Corresponding Authorship
    • Engineering Native Biological Complexity from the Inside–out and Outside–in.
  • Munoz-Robles, B.G. & DeForest, C.A. Irreversible Light-activated SpyLigation Mediates Split Protein Assembly in 4D. Nature Protocols 19, 1015–1052 (2024). (link, pdf)
    • Irreversible Light-activated SpyLigation Mediates Split Protein Assembly in 4D
  • Gharios, R., Francis, R.M. & DeForest, C.A. Chemical and Biological Engineering Strategies to Make and Modify Next-generation Hydrogel Biomaterials. Matter, 6, 4195-4244 (2023). (link, pdf)
    • Chemical and Biological Engineering Strategies to Make and Modify Next-generation Hydrogel Biomaterials
  • Rapp, T.R. & DeForest, C.A. Tricolor Visible Wavelength-selective Photodegradable Hydrogel Biomaterials. Nature Communications, 14, 5250 (2023). (link, pdf)
    • Tricolor Visible Wavelength-selective Photodegradable Hydrogel Biomaterials
  • Wu, K.-L., Bretherton, R.C., Davis, J. & DeForest, C.A. Pharmacological Regulation of Protein-polymer Hydrogel Stiffness. RSC Advances, 13, 24487 (2023). (link, pdf)
    • Pharmacological regulation of protein-polymer hydrogel stiffness
  • Francis, R.M. & DeForest, C.A. 4D Biochemical Photocustomization of Hydrogel Scaffolds for Spatiotemporally Heterogeneous Tissue Engineering. Accounts of Materials Research, 4, 704–715 (2023). (link, pdf)
    • 4D Biochemical Photocustomization of Hydrogel Scaffolds for Spatiotemporally Heterogeneous Tissue Engineering
  • Ruskowitz, E.R., Munoz-Robles, B.G., Strange, A.C., Butcher, C.H., Kurniawan, S., Filteau, J.R. & DeForest, C.A. Spatiotemporal Functional Assembly of Split Protein Pairs through a Light-Activated SpyLigation. Nature Chemistry, 15, 694–704 (2023). (link, pdf)
    • Spatiotemporal Functional Assembly of Split Protein Pairs through a Light-Activated SpyLigation
  • Bretherton, R.C., Haack, A.J., Kopyeva, I., Rahman, F., Kern, J.D., Bugg, D., Theberge, A.B., Davis, J. & DeForest, C.A. User-controlled 4D Biomaterial Degradation with Substrate-selective Sortase Transpeptidases for Single-cell Biology. Advanced Materials, 35, 2209904 (2023). (link, pdf)
    • *This article appears on the cover of the May 2023 issue of Advanced Materials User-controlled 4D Biomaterial Degradation with Substrate-selective Sortase Transpeptidases for Single-cell Biology
  • Bishop, B.P. & DeForest, C.A. A Decade with DYSS: Lessons Learned and Looking Forward. Chemical Engineering Education, 56, 137-146 (2022). (link, pdf)
    • A Decade with DYSS: Lessons Learned and Looking Forward
  • Uto, K., Tanimoto, R. & DeForest, C.A. Engineered 3D Matrices with Spatiotemporally Tunable Properties. Material-based Mechanobiology, Royal Society of Chemistry. Cambridge, UK. 282-308 (2022). (link, pdf)
    • Engineered 3D Matrices with Spatiotemporally Tunable Properties
  • Bugg, D., Bailey, L.R.J., Bretherton, R.C., Beach, K.E., Reichardt, I.M., Robeson, K.Z., Reese, A., Gunaje, J., Flint, G., DeForest, C.A., Stempien-Otero, A. & Davis, J. MBNL1 Drives Dynamic Transitions Between Fibroblasts and Myofibroblasts in Cardiac Wound Healing. Cell Stem Cell, 29, 419-433 (2022). (link, pdf)
    • MBNL1 Drives Dynamic Transitions Between Fibroblasts and Myofibroblasts in Cardiac Wound Healing
  • Hinman, S.S., Huling, J., Wang, Y., Wang, H., Bretherton, R.C., DeForest, C.A. & Allbritton, N.L. Magnetically-propelled Fecal Surrogates for Modeling the Impact of Solid-induced Shear Forces on Primary Colonic Epithelial Cells. Biomaterials, 276, 121059 (2021). (link, pdf)
    • Magnetically-propelled Fecal Surrogates for Modeling the Impact of Solid-induced Shear Forces on Primary Colonic Epithelial Cells
  • Rapp, T.R. & DeForest, C.A. Targeting Drug Delivery with Light: A Highly Focused Approach. Advanced Drug Delivery Reviews, 171, 94-107 (2021). (link, pdf)
    • Targeting Drug Delivery with Light: A Highly Focused Approach
  • Bretherton, R.C. & DeForest, C.A. The Art of Engineering Biomimetic Cellular Microenvironments. ACS Biomaterials Science & Engineering, 7, 3997-4008 (2021). (link, pdf)
    • The Art of Engineering Biomimetic Cellular Microenvironments
  • Batalov, I., Stevens, K.R. & DeForest, C.A. Photopatterned Biomolecule Immobilization to Guide 3D Cell Fate in Natural Protein-based Hydrogels. Proceedings of the National Academy of Sciences of the United States of America, 118, e2014194118 (2021). (link, pdf)
    *This article has been highlighted in UW News, EurekAlert!, Nanowerk, Bioengineer.org, Phys.org, and others.
    • Photopatterned Biomolecule Immobilization to Guide 3D Cell Fate in Natural Protein-based Hydrogels
  • Munoz-Robles, B.G., Kopyeva, I. & DeForest, C.A. Surface Patterning of Hydrogel Biomaterials to Probe and Direct Cell-Matrix Interactions. Advanced Materials Interfaces, 7, 2001198 (2020). (link, pdf)
    *This article appears on the cover of the November 2020 issue of Advanced Materials Interfaces
    • Surface Patterning of Hydrogel Biomaterials to Probe and Direct Cell-Matrix Interactions
  • Corbett, D.C., Grigoryan, B., Batalov, I., Regier, M., DeForest, C.A., Miller, J.S. & Stevens, K.R. Thermofluidic Heat Exchangers for Actuation of Transcription in Artificial Tissues. Science Advances, 6, eabb9062 (2020). (link, pdf)
    *This article has been highlighted in UW ISCRM News, EurekAlert!, Nanowerk, and others.
    • Thermofluidic Heat Exchangers for Actuation of Transcription in Artificial Tissues
  • Bugg, D., Bretherton, R., Kim, P., Olszewski, E., Nagle, A., Chu, N., Gunaje, J., DeForest, C.A., Stevens, K., Kim, D-H. & Davis, J. Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals. Circulation Research, 127, 1306-1322 (2020). (link, pdf)
    • Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals
  • Mandrycky, C., Williams, N.P., Batalov, I., El-Nachef, D., Davis, J., Kim, D-H., DeForest, C.A., Zheng, Y., Stevens, K.R. & Sniadecki, N.J. Engineering Heart Morphogenesis. Trends in Biotechnology, 38, 835-845 (2020). (link, pdf)
    *This article appears on the cover of the August 2020 issue of Trends in Biotechnology
    • Engineering Heart Morphogenesis
  • Rapp, T. & DeForest, C.A.* Visible Light-Responsive Dynamic Biomaterials - Going Deeper and Triggering More. Advanced Healthcare Materials, 9, 1901553 (2020). (link, pdf)
    • Visible Light-Responsive Dynamic Biomaterials - Going Deeper and Triggering More
  • Sisso, A., Boit, M.O. & DeForest, C.A.* Self-Healing Injectable Gelatin Hydrogels for Localized Therapeutic Cell Delivery. Journal of Biomedical Materials Research: Part A, 108, 1112-1121 (2020). (link, pdf)
    • Self-Healing Injectable Gelatin Hydrogels for Localized Therapeutic Cell Delivery
  • Arakawa, C.K., Gunnarsson, C., Bernabeu, M., Howard, C., Phong, K., Yang, E., DeForest, C.A.*, Smith, J.* & Zheng, Y.* Biophysical and Biomolecular Interactions of Malaria-Infected Erythrocytes in Engineered Human Capillaries. Science Advances, 6, eaay7243 (2020). (link, pdf) *Co-Corresponding Authorship
    *This article has been highlighted in Science Daily, Drug Target Review, MedicalXPress, Medical News, Biomedical Picture of the Day, 3DMedNet, and UW ISCRM News.
    • Biophysical and Biomolecular Interactions of Malaria-Infected Erythrocytes in Engineered Human Capillaries
  • Lee, U.N., Day, J.H., Haack, A.J., Bretherton, R.C., Lu, W., DeForest, C.A.*, Theberge, A.B.* & Berthier, E.* Layer-by-Layer Fabrication of 3D Hydrogel Structures Using Open Microfluidics. Lab on a Chip, 20, 525-536 (2020). (link, pdf) *Co-Corresponding Authorship
    • Layer-by-Layer Fabrication of 3D Hydrogel Structures Using Open Microfluidics
  • Shadish, J.A. & DeForest, C.A. Site-Selective Protein Modification: From Functionalized Proteins to Functional Biomaterials. Matter, 2, 50-77 (2020). (link, pdf)
    • Site-Selective Protein Modification: From Functionalized Proteins to Functional Biomaterials
  • Uto, K., Arakawa, C.K. & DeForest C.A.. Next-Generation Biomaterials for Culture and Manipulation of Stem Cells. Cold Spring Harbor Perspectives in Biology, a035691 (2019). (link, pdf)
    • Next-Generation Biomaterials for Culture and Manipulation of Stem Cells
  • Nagao, R.J., Marcu, R., Wang, Y., Wang, L., Arakawa, C.K., DeForest C.A., Chen J., López, J.A. & Zheng, Y. Transforming Endothelium with Platelet‐Rich Plasma in Engineered Microvessels. Advanced Science, 6, 1901725 (2019). (link, pdf)
    • Transforming Endothelium with Platelet‐Rich Plasma in Engineered Microvessels
  • Shadish, J.A., Strange, A.C. & DeForest, C.A. Genetically Encoded Photocleavable Linkers for Patterned Protein Release from Biomaterials. Journal of the American Chemical Society, 141, 15619-15625 (2019). (link, pdf)
    *This article appears on the cover of the October 2019 issue of JACS and was the subject of a Front Matter article in the Proceedings of the National Academy of Sciences. (link, pdf)
    • Genetically Encoded Photocleavable Linkers for Patterned Protein Release from Biomaterials
  • Gawade, P.G., Shadish, J.A., Badeau, B.A. & DeForest, C.A. Logic-Based Delivery of Site-Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials. Advanced Materials, 31, 1902462 (2019). (link, pdf)
    *This article was highlighted as the subject of a feature article in Chemistry World (link, pdf).
    • Logic-Based Delivery of Site-Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials
  • Shadish, J.A., Benuska, G.M. & DeForest, C.A. Bioactive Site-Specifically Modified Proteins for 4D Patterning of Gel Biomaterials. Nature Materials, 18, 1005-1014 (2019). (link, pdf)
    *This article was highlighted as the subject of a News & Views article in Nature Materials (link, pdf), a Research Highlight in Nature Reviews Materials (link, pdf), and a Spotlight article in Trends in Biotechnology (link, pdf). It received additional news coverage from Phys.org, NanoWerk, EurekAlert, NewsWise, LongRoom, Photonics.com, Medical News, Genetic Engineering & Biotechnology News, and UW News.
    • Bioactive Site-Specifically Modified Proteins for 4D Patterning of Gel Biomaterials
  • Badeau, B.A. & DeForest, C.A. Programming Stimuli-Responsive Behavior into Biomaterials. Annual Reviews of Biomedical Engineering, 21, 241-265 (2019). (link, pdf)
    • Programming Stimuli-Responsive Behavior into Biomaterials
  • Ruskowitz, E.R. & DeForest, C.A. Proteome-wide Analysis of Cellular Response to Ultraviolet Light for Biomaterial Synthesis and Modification. ACS Biomaterials Science & Engineering, 5, 2111-2116 (2019). (link, pdf)
    • Proteome-wide Analysis of Cellular Response to Ultraviolet Light for Biomaterial Synthesis and Modification
  • Ruskowitz, E.R., Comerford, M.P., Badeau, B.A. & DeForest, C.A.. Logical Stimuli-Triggered Delivery of Small Molecules from Hydrogel Biomaterials. Biomaterials Science, 7, 542-546 (2019). (link, pdf)
    *This article was selected for the 2019 Emerging Investigator Award issue of Biomaterials Science.
    • Logical Stimuli-Triggered Delivery of Small Molecules from Hydrogel Biomaterials
  • Oksdath, M., Perrin, S.L., Bardy, C., Hilder, E.F., DeForest, C.A., Arrua, R.D. & Gomez, G.A. Synthetic Scaffolds to Control the Biochemical, Mechanical and Geometrical Environment of Stem Cell-Derived Brain Organoids. APL Bioengineering, 2, 041501 (2018). (link, pdf)
    *This review was chosen as an Editor Featured article.
    • Synthetic Scaffolds to Control the Biochemical, Mechanical and Geometrical Environment of Stem Cell-Derived Brain Organoids
  • Liu, L., Shadish, J.A., Arakawa, C.K., Shi, K., Davis, J. & DeForest, C.A. Cyclic Stiffness Modulation of Cell-Laden Protein-Polymer Hydrogels in Response to User-Specified Stimuli including Light. Advanced Biosystems, 2, 1800240 (2018). (link, pdf)
    *This article appears on the cover of the December 2018 issue of Advanced Biosystems and was featured by: UW ISCRM News.
    • Cyclic Stiffness Modulation of Cell-Laden Protein-Polymer Hydrogels in Response to User-Specified Stimuli including Light
  • Fellin, C.R., Adelmund, S.M., Karis, D.G., Shafranek, R.T., Ono, R.J., Martin, C.G., Johnston, T.G. DeForest, C.A. & Nelson, A. Tunable Temperature- and Shear-Responsive Hydrogels Based on Poly(alkyl glycidyl ether)s. Polymer International, 68, 1238-1246 (2018). (link, pdf)
    • Tunable Temperature- and Shear-Responsive Hydrogels Based on Poly(alkyl glycidyl ether)s
  • DeForest, C.A. Introduction to Editorial Board Member: Professor Kristi S. Anseth. Bioengineering & Translational Medicine, 3, 182-184 (2018). (link, pdf)
    • Introduction to Editorial Board Member: Professor Kristi S. Anseth
  • Uto, K., Aoyagi, T., DeForest, C.A. & Ebara, M. Dynamic Alterations of Hepatocellular Function by On-Demand Elasticity and Roughness Modulation. Biomaterials Science, 6, 1002-1006 (2018). (link, pdf)
    • Dynamic Alterations of Hepatocellular Function by On-Demand Elasticity and Roughness Modulation
  • Badeau, B.A., Comerford, M.P., Arakawa, C.K., Shadish, J.A. & DeForest, C.A. Engineered Modular Biomaterial Logic Gates for Environmentally Triggered Therapeutic Delivery. Nature Chemistry, 10, 251-258 (2018). (link, pdf)
    *This article appears on the cover of the March 2018 issue of Nature Chemistry and holds the 10th highest Altmetric Attention Score of any Nature Chemistry paper to date. This article was highlighted as the subject of a feature article in Chemistry World (link, pdf). It has been further featured by: UW News, UW Daily, Chemical & Engineering News, Materials Today, Nano Werk, Newswise, GeekWire, EurekAlert!, Long Room, Science Newsline, Technology.org, Health Medicine Network, Phys.org, and the Signals Blog.
    • Engineered Modular Biomaterial Logic Gates for Environmentally Triggered Therapeutic Delivery
  • Ruskowitz, E.R. & DeForest, C.A. Photoresponsive Biomaterials for Targeted Drug Delivery and 4D Cell Culture. Nature Reviews Materials, 3, 17087 (2018). (link, pdf)
    *This article appears on the cover of the February 2018 issue of Nature Reviews Materials.
    • Photoresponsive Biomaterials for Targeted Drug Delivery and 4D Cell Culture
  • Adelmund, S.M., Ruskowitz, E.R., Farahani, P.E., Wolfe, J.V. & DeForest, C.A. Light-Activated Proteomic Labeling via Photocaged Bioorthogonal Non-Canonical Amino Acids. ACS Chemical Biology, 13, 573-577 (2018). (link, pdf)
    *The lead author of this article was featured in an ACS "Introducing Our Authors" write-up (link, pdf)
    • Light-Activated Proteomic Labeling via Photocaged Bioorthogonal Non-Canonical Amino Acids
  • Arakawa, C.K., Badeau, B.A., Zheng, Y. & DeForest, C.A. Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation. Advanced Materials, 29, 1703156 (2017). (link, pdf)
    *This article appears on the cover of the October 2017 issue of Advanced Materials and was featured in UW Medicine News.
    • Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation
  • Farahani, P.E., Adelmund, S.M., Shadish, J.A. & DeForest, C.A. Photomediated Oxime Ligation as a Bioorthogonal Tool for Spatiotemporally-Controlled Hydrogel Formation and Modification. Journal of Materials Chemistry B. 5, 4435-4442 (2017) (link, pdf)
    *This article was selected for the 2017 Emerging Investigator Award issue of the Journal of Materials Chemistry B, and appears on the cover of the June 2017 issue. More information is available here.
    • Photomediated Oxime Ligation as a Bioorthogonal Tool for Spatiotemporally-Controlled Hydrogel Formation and Modification
  • Arakawa, C.K. & DeForest, C.A. Designing Smart Biomaterials to Mimic & Control the Stem Cell Niche: Polymer Design and Development. Biology and Engineering of Stem Cell Niches, Elsevier. Oxford, UK. 295-314 (2017) (link, pdf)
    • Biology and Engineering of Stem Cell Niches
  • Swift, B.J., Shadish, J.A., DeForest, C.A. & Baneyx, F. Streamlined Synthesis and Assembly of a Hybrid Sensing Architecture with Solid Binding Proteins and Click Chemistry. Journal of the American Chemical Society, 139, 3958-3961 (2017) (link, pdf)
    • Streamlined Synthesis and Assembly of a Hybrid Sensing Architecture with Solid Binding Proteins and Click Chemistry
  • Uto, K. & DeForest, C.A. 時空間制御バイオマテリアルを用いた細胞力学記憶メカニズムの解明 Spatiotemporally Tunable Biomaterials for Revealing the Mechanism of Cellular Mechanical Memory (Article in Japanese). Journal of Japanese Biomaterials, 35, 36-41 (2017). (link, pdf)
    • Spatiotemporally Tunable Biomaterials for Revealing the Mechanism of Cellular Mechanical Memory
  • Uto, K., Aoyagi, T., DeForest, C.A., Hoffman, A.S. & Ebara, M. A Combinational Effect of “Bulk” and “Surface” Shape-Memory Transitions on the Regulation of Cell Alignment. Advanced Healthcare Materials, 6, 1601439 (2017). (link, pdf)
    • A Combinational Effect of “Bulk” and “Surface” Shape-Memory Transitions on the Regulation of Cell Alignment
  • Uto, K., Tsui, J.H., DeForest, C.A.* & Kim, D.H. Dynamically Tunable Cell Culture Platforms for Tissue Engineering and Mechanobiology. Progress in Polymer Science, 65, 53-82 (2016). (link, pdf) *Co-Corresponding Authorship
    • Dynamically Tunable Cell Culture Platforms for Tissue Engineering and Mechanobiology
  • Tibbitt, M.W., Shadish, J.A. & DeForest, C.A. Photopolymers for Multiphoton Lithography in Biomaterials and Hydrogels. Appears in Multiphoton Lithography: Techniques, Materials, and Applications, Wiley Publishing, 183-220 (2016). (link, pdf)
    • Photopolymers for Multiphoton Lithography in Biomaterials and Hydrogels
  • Uto, K., DeForest, C.A. & Kim, D.H. Soft Shape-Memory Materials. Appears in Biomaterials Nanoarchitectonics, Elsevier Inc, 237-251 (2015). (link, pdf)
    • Soft Shape-Memory Materials
  • Urrios, A., Parra-Cabrera, C., Bhattacharjee, N., Gonzalez-Suarez, A.M., Rigat-Brugarolas, L.G., Nallapatti, U., Samitier, J., DeForest, C.A., Posas, F., Garcia-Cordero, J.L. & Folch, A. 3D-printing of transparent bio-microfluidic devices in PEG-DA. Lab on a Chip, 16, 2287-2294 (2016). (link, pdf)
    • 3D-printing of transparent bio-microfluidic devices in PEG-DA
  • DeForest, C.A.* & Tirrell, D.A.* A Photoreversible Protein-Patterning Approach for Guiding Stem Cell Fate in Three-Dimensional Gels. Nature Materials, 14, 523-531 (2015). (link, pdf) *Co-Corresponding Authorship
    • A Photoreversible Protein-Patterning Approach for Guiding Stem Cell Fate in Three-Dimensional Gels
  • Adzima, B.J., Kloxin, C.J., DeForest, C.A., Anseth, K.S. & Bowman, C.N. 3D Photofixation Lithography in Diels–Alder Networks. Macromolecular Rapid Communications, 33, 2092-2096 (2012). (link, pdf)
    • 3D Photofixation Lithography in Diels–Alder Networks
  • Kloxin, A.M., Lewis, K.J.R., DeForest, C.A., Seedorf, G.J., Tibbitt, M.W., Balasubramaniam, V & Anseth, K.S. Responsive Culture Platform to Examine the Influence of Microenvironmental Geometry on Cell Function in 3D. Integrative Biology, 4, 1540-1549 (2012). (link, pdf)
    • Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D
  • DeForest, C.A. & Anseth, K.S. Advances in Bioactive Hydrogels to Probe and Direct Cell Fate. Annual Review of Chemical and Biomolecular Engineering, 3, 421-444 (2012). (link, pdf)
    • Bioactive Hydrogels for Regenerative Medicine
  • DeForest, C.A. & Anseth, K.S. Photoreversible Patterning of Biomolecules within Click-based Hydrogels. Angewandte Chemie International Edition, 51, 1816-1819 (2012). (link, pdf)
    *This article appears on the cover of the February 2012 issue of Angewandte and was selected as a “Very Important Paper” by the journal editors. It also was featured in Nature, Angewandte Chemie, and Lab on a Chip.
    • Photoreversible Patterning of Biomolecules within 3D Click Gels
  • DeForest, C.A. & Anseth, K.S. Cytocompatible Click-based Hydrogels with Dynamically-Tunable Properties through Orthogonal Photoconjugation and Photocleavage Reactions. Nature Chemistry, 3, 925-931 (2011). (link, pdf)
    *This article appears on the cover of the December 2011 issue of Nature Chemistry and has been highlighted in Chemistry World.
    • Cytocompatible Click-based Hydrogels with Dynamically-Tunable Properties through Orthogonal Photoconjugation and Photocleavage Reactions
  • Adzima, B.J., Tao, Y., Kloxin, C.J., DeForest, C.A., Anseth, K.S. & Bowman, C.N. Spatial and Temporal Control of the Alkyne–Azide Cycloaddition by Photoinitiated Cu(II) Reduction. Nature Chemistry, 3, 256-261 (2011). (link, pdf)
    • Spatial and Temporal Control of the Alkyne–Azide Cycloaddition by Photoinitiated Cu(II) Reduction
  • Sims, E.A., DeForest, C.A. & Anseth, K.S. A Mild, Large-Scale Synthesis of 1,3-Cyclooctanedione: Expanding Access to Difluorinated Cyclooctyne for Copper-Free Click Chemistry. Tetrahedron Letters, 52, 1871-1873 (2011). (link, pdf)
    *This article was featured by Vertical News
    • A Mild, Large-Scale Synthesis of 1,3-Cyclooctanedione: Expanding Access to Difluorinated Cyclooctyne for Copper-Free Click Chemistry
  • DeForest, C.A., Sims, E.A. & Anseth, K.S. Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture. Chemistry of Materials, 22, 4783-90 (2010). (link, pdf)
    • Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture
  • Johnson, L.M., DeForest, C.A., Pendurti, A., Anseth, K.S. & Bowman, C.N. Formation of Three-Dimensional Hydrogel Multilayers Using Enzyme-Mediated Redox Chain Initiation. ACS Applied Material Interfaces, 2, 1963-1972 (2010). (link, pdf)
    • Formation of Three-Dimensional Hydrogel Multilayers Using Enzyme-Mediated Redox Chain Initiation
  • Lawson, M.C., Hoth, K.B., DeForest, C.A., Bowman, C.N. & Anseth, K.S. Inhibition of Staphylococcus epidermidis Biofilms using Polymerizable Vancomycin Derivatives. Clin Orthop Relat Res, 468, 2081-2091 (2010). (link, pdf)
    • Inhibition of Staphylococcus epidermidis Biofilms using Polymerizable Vancomycin Derivatives
  • DeForest, C.A., Polizzotti, B.D. & Anseth, K.S. Sequential Click Reactions for Synthesizing and Patterning 3D Cell Microenvironments. Nature Materials, 8, 659-664 (2009). (link, pdf)
    *This article has been highlighted in Nature, Chemistry World, F1000, as well as others
    • Sequential Click Reactions for Synthesizing and Patterning 3D Cell Microenvironments
  • Benton, J.A., DeForest, C.A., Vivekanandan, V. & Anseth, K.S. Photocrosslinking of Gelatin Macromers to Synthesize Porous Hydrogels that Promote Valvular Interstitial Cell Function. Tissue Engineering Part A, 15 3221-3230 (2009). (link, pdf)
    • Tunable Microporous Photocrosslinking of Gelatin Macromers to Synthesize Porous Hydrogels that Promote Valvular Interstitial Cell Function  

    Cover Gallery

  • Bioengineering & Translational Medicine 2024 Vol 9 Issue 5 (pdf)
    • Nealy 2024 BioTM Cover
  • Advanced Science 2024 Vol 11 Issue 12 (pdf)
    • Bennett 2024 Advanced Science Cover
  • Advanced Materials 2023 Vol 35 Issue 19 (pdf)
    • Bretherton 2023 Advanced Materials Cover
  • Advanced Materials Interfaces 2020 Vol 7 Issue 21 (pdf)
    • Munoz-Robles 2020 Advanced Materials Interfaces Cover
  • Trends in Biotechnology 2020 Vol 38 Issue 8 (high resolution png)
    • Mandrycky 2020 TIBTECH Cover
  • Journal of the Americal Chemical Society (JACS) 2019 Vol 141 Issue 39 (high resolution jpg)
    • Shadish 2019 JACS Cover
  • Advanced Materials 2019 Vol 31 Issue 33 (pdf)
    • Gawade 2019 Advanced Materials Cover
  • Advanced Biosystems 2018 Vol 2 Issue 12 (pdf)
    • Liu 2018 Advanced Biosystems Cover
  • Nature Chemistry 2018 Vol 10 Issue 3 (pdf)
    • Badeau 2018 Nature Chemistry Cover
  • Nature Reviews Materials 2018 Vol 3 Issue 2 (pdf)
    • Ruskowitz 2018 Nature Revies Materials Cover
  • Advanced Materials 2017 Vol 29 Issue 37 (pdf)
    • Farahani 2017 JMCb Cover
  • Chemical Engineering Progress August 2017 (pdf)
    • DeForest 2017 CEP Cover
  • Journal of Materials Chemistry B 2017 Issue 23 (pdf)
    • Farahani 2017 JMCb Cover
  • Angewandte Chemie International Edition 2012 Vol 51 Issue 8 (pdf)
    • DeForest Angewandte Chemie 2012 Cover
  • Nature Chemistry 2011 Vol 3 Issue 12 (pdf)
    • DeForest Nature Chemistry 2011 Cover

    Research Highlights

  • DeForest, C.A., Zhang, H., Memic, A., Dokmeci, M.R. & Khademhosseini, A. Research Highlights. Lab on a Chip 12, 3540-3542 (2012). (link, pdf)
  • Selimović, Š., DeForest, C.A., Dokmeci, M.R. & Khademhosseini, A. Research Highlights. Lab on a Chip 12, 2995-2997 (2012). (link, pdf)
  • Selimović, Š., DeForest, C.A., Dokmeci, M.R. & Khademhosseini, A. Research Highlights. Lab on a Chip 12, 2289-2291 (2012). (link, pdf)
  • Selimović, Š., DeForest, C.A., Dokmeci, M.R. & Khademhosseini, A. Research Highlights. Lab on a Chip 12, 2094-2096 (2012). (link, pdf)
  • Selimović, Š., DeForest, C.A., Dokmeci, M.R. & Khademhosseini, A. Research Highlights. Lab on a Chip 12, 2015-2017 (2012). (link, pdf)
  • Selimović, Š., DeForest, C.A., Dokmeci, M.R. & Khademhosseini, A. Research Highlights. Lab on a Chip 12, 1739-1741 (2012). (link, pdf)

    • Google Scholar

    An up-to-date list of publications can be found through the group's Google Scholar page:

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